Multispecies probiotics combination prevents ovalbumin-induced airway hyperreactivity in mice
Allergol. immunopatol
; 46(4): 354-360, jul.-ago. 2018.
Article
in En
| IBECS
| ID: ibc-177866
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND: Probiotics could be beneficial to health and some of them have shown to modulate immune responses. AIM: The aim of this study is to investigate if the probiotic strains including Lactobacillus and Pediococcus strains are able to alleviate allergic reactions in an ovalbumin-induced airway allergy model. METHODS: Lactobacillus multi-species preparation (LMP) was gavaged to BALB/c for total six weeks and BALB/c was challenged with ovalbumin in the last two weeks. A barometric whole-body plethysmography was used to assess enhanced pause (Penh) of airway hyperreactivity (AHR). Immunoglobulins (Ig) such as IgE, IgG1, IgG2a and cytokines such as IL-12, IFN-gamma, IL-4, IL-5, TNF-alfa and IL-13 in bronchoalveolar lavage fluid were assayed using ELISA kits. RESULTS: The results showed this LMP significantly reduced Th2 cytokines and enhanced Th1 cytokines production. OVA-specific IgE and IgG1 was lower in the probiotics-treated mice whereas IgG2a was increased. Most importantly, this murine model showed LMP supplementation significantly reduced AHR. CONCLUSIONS: Overall, this Lactobacillus multi-species preparation seemed to suppress OVA-sensitized airway hyperreactivity, thus serving as a possible candidate for therapeutic uses for allergic airway symptoms
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Bronchial Hyperreactivity
/
Probiotics
/
Lung
Limits:
Animals
Language:
En
Journal:
Allergol. immunopatol
Year:
2018
Document type:
Article